Sialic acid glycoproteins inhibit in vitro and in vivo replication of rotaviruses.

@article{Yolken1987SialicAG,
  title={Sialic acid glycoproteins inhibit in vitro and in vivo replication of rotaviruses.},
  author={Robert Yolken and Rodney E. Willoughby and S. B. Wee and R L Miskuff and Steven L. Vonderfecht},
  journal={The Journal of clinical investigation},
  year={1987},
  volume={79 1},
  pages={
          148-54
        }
}
We investigated the interactions of rotaviruses with glycoproteins and cells that support rotaviral replication. We found that a wide range of naturally occurring glycoproteins, including ovalbumins and ovomucoids from chicken and turkey eggs, and mucin derived from bovine submaxillary glands, inhibit the replication of rotaviruses in MA-104 cells. Our studies further indicated that the glycoproteins bind directly to rotaviruses and that virus-glycoprotein binding is dependent largely upon… CONTINUE READING

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