Sialic acid: a preventable signal for pneumococcal biofilm formation, colonization, and invasion of the host.

@article{Trappetti2009SialicAA,
  title={Sialic acid: a preventable signal for pneumococcal biofilm formation, colonization, and invasion of the host.},
  author={Claudia Trappetti and Aras Kadioglu and Melissa T. Carter and Jasvinder Hayre and Francesco Iannelli and Gianni Pozzi and P. W. Andrew and Marco R Oggioni},
  journal={The Journal of infectious diseases},
  year={2009},
  volume={199 10},
  pages={1497-505}
}
The correlation between carbohydrate availability, pneumococcal biofilm formation, nasopharyngeal colonization, and invasion of the host has been investigated. Of a series of sugars, only sialic acid (i.e., N-acetylneuraminic acid) enhanced pneumococcal biofilm formation in vitro, at concentrations similar to those of free sialic acid in human saliva. In a… CONTINUE READING