Siah2 regulates tight junction integrity and cell polarity through control of ASPP2 stability

@inproceedings{Kim2014Siah2RT,
  title={Siah2 regulates tight junction integrity and cell polarity through control of ASPP2 stability},
  author={Hyungsoo Kim and Guisepinna Claps and Andreas Moeller and David D. L. Bowtell and Xin Lu and Ze'ev A Ronai},
  booktitle={Oncogene},
  year={2014}
}
Changes in cell adhesion and polarity are closely associated with epithelial cell transformation and metastatic capacity. The tumor suppressor protein ASPP (Apoptosis-Stimulating Proteins of p53) 2 has been implicated in control of cell adhesion and polarity through its effect on the PAR complex. Here we demonstrate that under hypoxic conditions, the ubiquitin ligase Siah (seven in absentia homolog)2 controls ASPP2 availability, with concomitant effect on epithelial cell polarity. LC-MS/MS… CONTINUE READING
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Autoregulatory control of the p53 response by Siah-1L-mediated HIPK2 degradation

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