Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors.

@article{Qi2010Siah2dependentCA,
  title={Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors.},
  author={Jianfei Qi and Koh Nakayama and Robert Cardiff and Alexander D. Borowsky and Karen Kaul and Roy D. Williams and Stan Stanislaw Krajewski and Dan Mercola and Philip M. Carpenter and David D. L. Bowtell and Ze'ev A Ronai},
  journal={Cancer cell},
  year={2010},
  volume={18 1},
  pages={23-38}
}
Neuroendocrine (NE) phenotype, seen in >30% of prostate adenocarcinomas (PCa), and NE prostate tumors are implicated in aggressive prostate cancer. Formation of NE prostate tumors in the TRAMP mouse model was suppressed in mice lacking the ubiquitin ligase Siah2, which regulates HIF-1alpha availability. Cooperation between HIF-1alpha and FoxA2, a transcription factor expressed in NE tissue, promotes recruitment of p300 to transactivate select HIF-regulated genes, Hes6, Sox9, and Jmjd1a. These… CONTINUE READING
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