Siah-1 interacts with the intracellular region of polycystin-1 and affects its stability via the ubiquitin-proteasome pathway.

@article{Kim2004Siah1IW,
  title={Siah-1 interacts with the intracellular region of polycystin-1 and affects its stability via the ubiquitin-proteasome pathway.},
  author={Hyunho Kim and Woocho Jeong and Kwangseog Ahn and Curie Ahn and Seongman Kang},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2004},
  volume={15 8},
  pages={2042-9}
}
Autosomal dominant polycystic kidney disease, characterized by extensive formation of renal cysts and progressive renal failure, is a genetic disorder caused by mutations in the PKD1 and PKD2 genes. The PKD1 gene product, polycystin-1, is a transmembrane protein with its N-terminus facing the extracellular region and C-terminus facing the cytoplasm. Polycystin-1 seems to be involved in regulating cell growth and maturation, but the precise mechanisms are not yet well defined. For investigating… CONTINUE READING