SiMa, a new neuroblastoma cell line combining poor prognostic cytogenetic markers with high adrenergic differentiation.

@article{Marini1999SiMaAN,
  title={SiMa, a new neuroblastoma cell line combining poor prognostic cytogenetic markers with high adrenergic differentiation.},
  author={Paolo Marini and Roderick A F Macleod and Claudia Treuner and Gernot Bruchelt and W. B{\"o}hm and Hartwig Wolburg and Paul Schweizer and R Girgert},
  journal={Cancer genetics and cytogenetics},
  year={1999},
  volume={112 2},
  pages={161-4}
}
We describe the establishment and characterization of a new neuroblastoma (Nb) cell line, SiMa, carrying the major recurrent chromosome changes associated with poor prognosis Nb, including amplification of N-MYC by formation of double minutes (dmin), der(1)t(1;17)(p35;q12) and der(22)t(17;22)(q22;p13), and loss of chromosome 11, documented at both initiation and late passage. In contrast to these cytogenetic stigmata of poor prognosis, analysis of catecholamine synthesis by high pressure liquid… CONTINUE READING

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