Shuttling Tolerogenic Dendritic Cells across the Blood–Brain Barrier In Vitro via the Introduction of De Novo C–C Chemokine Receptor 5 Expression Using Messenger RNA Electroporation

@inproceedings{Laere2017ShuttlingTD,
  title={Shuttling Tolerogenic Dendritic Cells across the Blood–Brain Barrier In Vitro via the Introduction of De Novo C–C Chemokine Receptor 5 Expression Using Messenger RNA Electroporation},
  author={Maxime De Laere and Judith Derdelinckx and Mari Hassi and Mari Kerosalo and Heidi Oravam{\"a}ki and J. S. H. van den Bergh and Zwi Berneman and Nathalie Cools},
  booktitle={Front. Immunol.},
  year={2017}
}
The use of tolerance-inducing dendritic cells (tolDCs) has been proven to be safe and well tolerated in the treatment of autoimmune diseases. Nevertheless, several challenges remain, including finding ways to facilitate the migration of cell therapeutic products to lymph nodes, and the site of inflammation. In the treatment of neuroinflammatory diseases, such as multiple sclerosis (MS), the blood-brain barrier (BBB) represents a major obstacle to the delivery of therapeutic agents to the… CONTINUE READING
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