Shp2 acts downstream of SDF-1alpha/CXCR4 in guiding granule cell migration during cerebellar development.

@article{Hagihara2009Shp2AD,
  title={Shp2 acts downstream of SDF-1alpha/CXCR4 in guiding granule cell migration during cerebellar development.},
  author={Kazuki Hagihara and Eric Erquan Zhang and Yue Hai Ke and Guofa Liu and Jan-jan Liu and Yi Rao and Gen-sheng Feng},
  journal={Developmental biology},
  year={2009},
  volume={334 1},
  pages={
          276-84
        }
}
Shp2 is a non-receptor protein tyrosine phosphatase containing two Src homology 2 (SH2) domains that is implicated in intracellular signaling events controlling cell proliferation, differentiation and migration. To examine the role of Shp2 in brain development, we created mice with Shp2 selectively deleted in neural stem/progenitor cells. Homozygous mutant mice exhibited early postnatal lethality with defects in neural stem cell self-renewal and neuronal/glial cell fate specification. Here we… Expand
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