Shox2 regulates progression through chondrogenesis in the mouse proximal limb.

@article{Bobick2012Shox2RP,
  title={Shox2 regulates progression through chondrogenesis in the mouse proximal limb.},
  author={Brent E Bobick and John Cobb},
  journal={Journal of cell science},
  year={2012},
  volume={125 Pt 24},
  pages={6071-83}
}
In humans, loss of SHOX gene function is responsible for the mesomelic short stature characteristic of Turner syndrome, Leri-Weill dyschondrosteosis, and Langer dysplasia. In a mouse model of SHOX deficiency, Prrx1-Cre-driven limb-specific deletion of the paralogous gene Shox2 results in severe rhizomelia. In this study, we show that Col2a1-Cre-driven deletion of Shox2 in developing chondrocytes also results in shortening of the stylopodial skeleton (i.e. humerus, femur) and that this… CONTINUE READING
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