Shouts, whispers and the kiss of death: directional secretion in T cells

  title={Shouts, whispers and the kiss of death: directional secretion in T cells},
  author={Morgan Huse and Emily J. Quann and Mark M. Davis},
  journal={Nature Immunology},
T cells use secreted soluble factors for highly specific intercellular communication and targeted cell killing. This specificity is achieved first through T cell receptor–mediated recognition of complexes of peptide and major histocompatibility complex displayed by appropriate antigen-presenting cells and then by the directed secretion of cytokines and lytic factors into the immunological synapse between the T cell and antigen-presenting cell. Studies have begun to probe the molecular basis for… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
73 Citations
67 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 73 extracted citations


Publications referenced by this paper.
Showing 1-10 of 67 references

Protein kinase Cδ regulates antigen receptor-induced lytic granule polarization in mouse CD8+ CTL

  • Ma, J.S
  • J. Immunol
  • 2007

Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist

  • M Huse
  • Immunity 27,
  • 2007

Similar Papers

Loading similar papers…