Shouts, whispers and the kiss of death: directional secretion in T cells

@article{Huse2008ShoutsWA,
  title={Shouts, whispers and the kiss of death: directional secretion in T cells},
  author={Morgan Huse and Emily J. Quann and Mark M. Davis},
  journal={Nature Immunology},
  year={2008},
  volume={9},
  pages={1105-1111}
}
T cells use secreted soluble factors for highly specific intercellular communication and targeted cell killing. This specificity is achieved first through T cell receptor–mediated recognition of complexes of peptide and major histocompatibility complex displayed by appropriate antigen-presenting cells and then by the directed secretion of cytokines and lytic factors into the immunological synapse between the T cell and antigen-presenting cell. Studies have begun to probe the molecular basis for… CONTINUE READING

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