Should we screen for globin gene mutations in blood samples with mean corpuscular volume (MCV) greater than 80 fL in areas with a high prevalence of thalassaemia?

@article{Chan2001ShouldWS,
  title={Should we screen for globin gene mutations in blood samples with mean corpuscular volume (MCV) greater than 80 fL in areas with a high prevalence of thalassaemia?},
  author={L. M. Chan and S. K. Ma and Amy Yuk-yin Chan and Sang Yun Ha and John S. Waye and Yu Lung Lau and David H. K. Chui},
  journal={Journal of clinical pathology},
  year={2001},
  volume={54 4},
  pages={317-20}
}
AIMS To investigate whether it is worthwhile, in areas where thalassaemia is common, to screen for globin gene mutations in subjects with a mean corpuscular volume (MCV) above 80 fL, especially in partners of known thalassaemia carriers. METHODS Blood samples from 95 subjects with MCV between 80 and 85 fL were screened for the presence of alpha globin gene mutations and the haemoglobin (Hb) E mutation. RESULTS Thirty four subjects harboured globin gene mutations. Of these, 31 had deletions… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 17 references

Detection of common deletional á - thalassaemia - 2 determinants by PCR

  • E Baysal, Huisman THJ
  • Am J Hematol
  • 1997

A reverse dot - blot method for rapid detection of non - deletional á thalassaemia

  • V Chan, Chan VWY, FE Chen
  • Br J Haematology
  • 1994

Comparison of the HbH inclusion test and a PCR test in routine screening for á thalassaemia in Hong Kong

  • Chan AYY, So CKC, LC Chan
  • J Clin Pathol
  • 1994

Type of á - globin gene frequencies in Chinese newborn babies in the Guangxi region , P . R . China

  • JB Zhao, L Zhao, YC Gu
  • Hemoglobin
  • 1994

Screening for thalassaemia and sickle hemoglobin

  • Chui DHK, JS Waye, D Chitayat
  • The Canadian Journal of Obstetrics / Gynecology…
  • 1993

Similar Papers

Loading similar papers…