Should we discount the laboratory origin of COVID-19?

@article{Segreto2021ShouldWD,
  title={Should we discount the laboratory origin of COVID-19?},
  author={Rossana Segreto and Yuri Deigin and Kevin McCairn and Alejandro Sousa and Dan Sirotkin and Karl Sirotkin and Jonathan J. Couey and Adrian Jones and Dao-Rong Zhang},
  journal={Environmental Chemistry Letters},
  year={2021},
  pages={1 - 15}
}
Abbreviations ACE2 Angiotensin-converting enzyme 2 FCS Furin cleavage site GBD Ganglioside-binding domain HS Heparan sulphate MERS-CoV Middle East respiratory syndrome-related coronavirus NTD N-terminal domain RBD Receptor binding domain RBM Receptor binding motif SARS-CoV Severe acute respiratory syndrome coronavirus SARS-CoV-2 Severe acute respiratory syndrome coronavirus type 2 SARS-r CoV SARS-related coronavirus TMPRSS Transmembrane serine protease WIV Wuhan Institute of Virology… 
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19 Citations
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19 Citations

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Citation Type

Lacunae in the natural origin of severe acute respiratory syndrome coronavirus 2
  • Deepa Revi
  • Medicine, Biology
    The Applied Biology & Chemistry Journal
  • 2021
TLDR
This perspective provides awareness of the peculiar features of SARS-CoV-2 and inspects the gaps in the natural zoonotic origin of the pandemic.
Lacunae in the natural origin of severe acute respiratory syndrome coronavirus 2
  • Deepa Revi
  • Medicine, Biology
    The Applied Biology & Chemistry Journal
  • 2021
TLDR
This perspective provides awareness of the peculiar features of SARS-CoV-2 and inspects the gaps in the natural zoonotic origin of the pandemic.
The SARS‐CoV‐2 origin dilemma: Zoonotic transfer or laboratory leak?
TLDR
Although stronger evidence supports the zoonotic transfer, inconclusive reports maintain the laboratory leak hypothesis alive, it is imperative to reach a factual conclusion to prevent future pandemics.
Meta-analysis to explain unknown causes of the origins of SARS-COV-2
Origins of the SARS Corona Virus 2
SARS-CoV-2 exhibits genomic features that are unusual for a natural virus. The U. S. federal government has funded research related to virus mutation in similar viruses in a laboratory in Wuhan,…
On Similarities and Differences of HIV and SARS Cov-2; Open Questions Relevant for COVID-19 Disease
  • E. Žerovnik
  • Education
    Journal of Biotechnology and Biomedicine
  • 2021
This paper is written from an educated bio-scientist’ perspective who follows studies about COVID-19 in order to better understand some relevant questions about the disease and vaccination. I first…
Critical Mutations of the SARS-CoV-2 Virus
TLDR
It is argued that looking at the mutations of the SARS-CoV-2 virus through a physical chemistry lens provides a deeper understanding of viral evolutionary trends, and advocate here the use of quantitative (mathematical) methods, based on physical chemistry foundations, to analyze viruses.
Thus spoke peptides: SARS-CoV-2 spike gene evolved in humans and then shortly in rats while the rest of its genome in horseshoe bats and then in treeshrews
TLDR
A new method is used to search for the original host of the ancestor of the SARS-CoV-2 virus and for the donor of its gene for the spike protein, the molecule responsible for binding to and entering human cells, suggesting that the ancestral coronavirus adapted to bats, but the spike gene donor was adapted to humans.
Immunological challenges of the “new” infections: corona viruses
  • A. Rees
  • Biology
    A New History of Vaccines for Infectious Diseases
  • 2022
What we know and what we need to know about the origin of SARS-CoV-2
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