Should we abandon quinine plus antibiotic for treating uncomplicated falciparum malaria? A systematic review and meta-analysis of randomized controlled trials

  title={Should we abandon quinine plus antibiotic for treating uncomplicated falciparum malaria? A systematic review and meta-analysis of randomized controlled trials},
  author={Tianzhang Song and Jintao Chen and Lilin Huang and Wenjia Gan and Hongling Yin and Juan Jiang and Tailong He and Huaiqiu Huang and Xuchu Hu},
  journal={Parasitology Research},
In this study, we compared the efficacies and adverse effects of quinine plus antibiotics and other anti-malaria drugs on treating uncomplicated falciparum malaria. By systematically searching the major databases PubMed, Embase, and the Cochrane Library, 14 randomized controlled trials (RCTs) including 1996 cases were identified. Then, we performed a systematic review and cumulative meta-analysis on these data. The primary outcome of these treatments was parasite failure at day 28. There was no… 
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Clindamycin plus quinine for treating uncomplicated falciparum malaria: a systematic review and meta-analysis
The evidence on the efficacy of clindamycin plus quinine as an alternative treatment for uncomplicated malaria is inconclusive and adequate powered trials are urgently required to compare this combination with artemisinin-based combinations.
Randomized controlled trial of artesunate plus tetracycline versus standard treatment (quinine plus tetracycline) for uncomplicated Plasmodium falciparum malaria in Brazil.
The results indicate that the combination of artesunate plus tetracycline is effective in the treatment of uncomplicated falciparum malaria and may provide a useful alternative to other treatment regimens.
Comparison of oral artesunate and quinine plus tetracycline in acute uncomplicated falciparum malaria.
Oral artesunate can be considered as an alternative drug for multiple-drug-resistant falciparum malaria; however, adverse effects, particularly neurotoxicity, should be closely monitored before its widespread use can be recommended.
Effective treatment of uncomplicated Plasmodium falciparum malaria with azithromycin-quinine combinations: a randomized, dose-ranging study.
Three- and five-day azithromycin-quinine combination therapy appears safe, well tolerated, and effective in curing drug-resistant P. falciparum malaria.
Artesunate-clindamycin versus quinine-clindamycin in the treatment of Plasmodium falciparum malaria: a randomized controlled trial.
Artesunate-clindamycin and other matching artemisinin-based combinations with a short plasma half-life merit further attention for use in regions in which the rate of transmission of malaria is high.
Clindamycin in combination with chloroquine or quinine is an effective therapy for uncomplicated Plasmodium falciparum malaria in children from Gabon.
The combination of clindamycin with chloroquine or quinine enhances parasite clearance and improves response to therapy.
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There is currently no indication that artemisinin resistance has reached Bangladesh, however, the fact that resistance has recently been reported from nearby Myanmar indicates an urgent need for close monitoring of artemis inin resistance in the region.
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Clindamycin in combination with quinine is a safe and effective treatment for multidrug-resistant P. falciparum malaria and may be of particular value in children and pregnant women, in whom tetracyclines are contraindicated.
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