Should vitamin D supplementation routinely be prescribed to children receiving antiepileptic medication?

  title={Should vitamin D supplementation routinely be prescribed to children receiving antiepileptic medication?},
  author={Maura Scott and Neil Corrigan and Thomas W Bourke and Andrew Thompson and Peter Mallett},
  journal={Archives of Disease in Childhood},
  pages={90 - 92}
You are the paediatric registrar at an epilepsy clinic. A mother of a 9-year-old patient with childhood absence epilepsy asks if he should be taking vitamin D. He is currently prescribed sodium valproate. You wonder if you should prescribe vitamin D supplementation alongside his antiepileptic medication. In children with a clinical diagnosis of epilepsy on antiepileptic drugs (AED) (population), is there evidence to suggest that they should receive supplemental vitamin D (intervention) to… 
1 Citations
Farmaci antiepilettici, vitamina D e mineralizzazione ossea: le evidenze e le azioni
The evidence suggests to prescribe a prophylaxis with vitamin D at 400 IU/day to children on antiepileptic therapy and without other risk factors and provide them with indications regarding correct eating, motor and sun exposure lifestyles.


Vitamin D deficiency in children with epilepsy: Do we need to detect and treat it?
There remains concern that children with epilepsy are at risk of poor bone health and that vitamin D therapy may be beneficial, and it is important that neurologists ensure that low-dose vitamin D supplementation should be prescribed and compliance followed up inChildren with epilepsy.
Oxford Centre for Evidence-based Medicine Levels of Evidence (January 2001)
  • Medicine, Psychology
  • 2014
Analysis based on clinically sensible costs or alternatives; systematic review(s) of the evidence; and including multi-way sensitivity analyses.
Two randomized vitamin D trials in ambulatory patients on anticonvulsants
In ambulatory adults on antiepileptic drugs, high-dose vitamin D therapy substantially increased bone mineral density at several skeletal sites and in children, both doses resulted in comparable increases in bone mass.
Prophylactic low-dose vitamin D (400 IU) may help to prevent vitamin D deficiency and low bone mineral density in children prescribed with AEDs (grade C)
    Vitamin D and bone health: a practical clinical guideline for management in children and young people
    • ROS
    • 2018
    Antiepileptic drugs (AEDs) are known to cause vitamin D deficiency in children with epilepsy (grade C)