Should the Gleason grading system for prostate cancer be modified to account for high-grade tertiary components? A systematic review and meta-analysis.

Abstract

The Gleason system for grading prostate cancer assigns a score on the basis of the most prevalent and second most prevalent grade. Several studies have investigated the clinical significance of a tertiary grade in radical prostatectomy samples. A systematic search of the published work identified seven studies that reported the prognostic value of a… (More)

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@article{Harnden2007ShouldTG, title={Should the Gleason grading system for prostate cancer be modified to account for high-grade tertiary components? A systematic review and meta-analysis.}, author={Patricia M Harnden and Michael D Shelley and Bernadette Coles and John N Staffurth and Malcom D Mason}, journal={The Lancet. Oncology}, year={2007}, volume={8 5}, pages={411-9} }