Should systematic reviews include non-randomized and uncontrolled studies? The case of acupuncture for chronic headache.

@article{Linde2002ShouldSR,
  title={Should systematic reviews include non-randomized and uncontrolled studies? The case of acupuncture for chronic headache.},
  author={Klaus Linde and Michael Scholz and Dieter Melchart and Stefan N. Willich},
  journal={Journal of clinical epidemiology},
  year={2002},
  volume={55 1},
  pages={
          77-85
        }
}
We aimed to investigate: (1) whether patient and intervention characteristics, design-independent quality aspects, and response rates differ between randomized and non-randomized trials of acupuncture for chronic headache; (2) whether non-randomized studies provide useful additional information (regarding long-term effects, prognostic factors, adverse effects, and generalizability); (3) reasons for potential differences in response rates. Studies including at least five patients and reporting… CONTINUE READING
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