Should research ethics change at the border?

  title={Should research ethics change at the border?},
  author={P. McNeill},
  journal={Medical Journal of Australia},
  • P. McNeill
  • Published 1998
  • Medicine
  • Medical Journal of Australia
Beyond that, when the health gains have occurred, then it may be possible to reduce the level of investment again. There also needs to be recognition, as Deeble indicates, of the higher levels of spending needed for delivering services to Aboriginal communities, many of which are in remote locations, and of the need to make the services culturally appropriate. As health status improves in any community there is the prospect that "diminishing returns" will set in. Once the easily achieved gains… Expand
Should research ethics change at the border?
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  • S. Geller, A. Patel, +4 authors R. Derman
  • Medicine
  • International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • 2004
In implementing a randomized clinical trial to reduce postpartum hemorrhage during childbirth in rural India, U.S. and Indian collaborators addressed three issues: the appropriateness of an ethical randomized controlled trial in the developing world, the inclusion of a placebo arm, and the relevance of informed consent in a semiliterate rural population. Expand
Pills, Politics, and Placebos
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Equipoise and the ethics of clinical research.
  • B. Freedman
  • Medicine
  • The New England journal of medicine
  • 1987
An alternative concept of equipoise is suggested, which would be based on present or imminent controversy in the clinical community over the preferred treatment, which is satisfied if there is genuine uncertainty within the expert medical community--not necessarily on the part of the individual investigator--about the preferredreatment. Expand
The ethics of clinical research in the Third World.
  • M. Angell
  • Medicine
  • The New England journal of medicine
  • 1997
An essential ethical condition for a randomized clinical trial comparing two treatments for a disease is that there be no good reason for thinking one is better than the other.1,2 Usually,Expand
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Administration of zidovudine during late pregnancy and delivery to prevent perinatal HIV transmission--Thailand, 1996-1998.
  • B. Sha
  • Medicine
  • MMWR. Morbidity and mortality weekly report
  • 1998
Preliminary trial results indicate that a short-term antenatal regimen of ZDV reduced the risk for perinatal HIV transmission by approximately half. Expand
Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group.
In pregnant women with mildly symptomatic HIV disease and no prior treatment with antiretroviral drugs during the pregnancy, a regimen consisting of zidovudine given ante partum and intra partum to the mother and to the newborn for six weeks reduced the risk of maternal-infant HIV transmission by approximately two thirds. Expand