Should parafibromin staining replace HRTP2 gene analysis as an additional tool for histologic diagnosis of parathyroid carcinoma?

@article{Cetani2007ShouldPS,
  title={Should parafibromin staining replace HRTP2 gene analysis as an additional tool for histologic diagnosis of parathyroid carcinoma?},
  author={Filomena Cetani and Elena Ambrogini and Paolo Viacava and Elena Pardi and Giovanni Fanelli and Antonio Giuseppe Naccarato and Simona Borsari and Monica Lemmi and P. Berti and Paolo Miccoli and Aldo Pinchera and Claudio Marcocci},
  journal={European journal of endocrinology},
  year={2007},
  volume={156 5},
  pages={547-54}
}
OBJECTIVE HRPT2 gene mutations are associated with parathyroid carcinomas, and absence of parafibromin immunoreactivity has been suggested as a diagnostic marker of malignancy. The aim of our study was to extend parafibromin studies in a series of benign and malignant parathyroid tumors and cross-validate the results of immunohistochemistry with those of HRPT2 analysis. DESIGN AND PATIENTS We performed parafibromin and cyclin D1 immunostaining and HRPT2 gene analysis using loss of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 42 extracted citations

Similar Papers

Loading similar papers…