Should minimal blood glucose variability become the gold standard of glycemic control?

@article{Hirsch2005ShouldMB,
  title={Should minimal blood glucose variability become the gold standard of glycemic control?},
  author={Irl B. Hirsch and Michael A. Brownlee},
  journal={Journal of diabetes and its complications},
  year={2005},
  volume={19 3},
  pages={
          178-81
        }
}
The Diabetes Complications and Control Trial (DCCT) established glycosylated hemoglobin (A1C) as the gold standard of glycemic control, with levels </=7% deemed appropriate for reducing the risk of vascular complications. Yet, even when A1Cs were comparable between intensively treated subjects and their conventionally treated counterparts, the latter group experienced a markedly higher risk of progression to retinopathy over time. Our speculative explanation, based on the discovery that… CONTINUE READING
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