Should laboratory mice be anaesthetized for tail biopsy?

@article{Arras2007ShouldLM,
  title={Should laboratory mice be anaesthetized for tail biopsy?},
  author={Margarete Arras and Andreas Rettich and Burkhardt Seifert and Hans Peter K{\"a}sermann and Thomas R{\"u}licke},
  journal={Laboratory animals},
  year={2007},
  volume={41 1},
  pages={30-45}
}
Tail biopsies are routinely taken to genotype genetically modified mice. However, the effect of this procedure on the wellbeing of the animals has rarely been investigated. Thus, it has not yet been clearly demonstrated to what extent the mice suffer from tail biopsy (TB) and for how long. The aim of our study was to assess the impact of a single TB on the physiological and behavioural parameters of adult mice and to investigate whether or not anaesthesia can be beneficial. Body weight (BW… CONTINUE READING