Should androgenic anabolic steroids be considered in the treatment regime of selected chronic obstructive pulmonary disease patients?

@article{Velema2012ShouldAA,
  title={Should androgenic anabolic steroids be considered in the treatment regime of selected chronic obstructive pulmonary disease patients?},
  author={Marieke S Velema and Bibi H B Kwa and W de Ronde},
  journal={Current Opinion in Pulmonary Medicine},
  year={2012},
  volume={18},
  pages={118–124}
}
Purpose of review Chronic obstructive pulmonary disease (COPD) is a widespread disease with high morbidity rates. Advanced stages can be complicated by unintentional weight loss and muscle wasting, which may contribute to increased morbidity and mortality. Reversal of weight loss increases muscle strength and exercise capacity and improves survival. This can partly be achieved by nutritional support, preferably combined with increase in exercise. Androgenic anabolic steroids (AASs), of which… 
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20 Citations

Anabolic-androgenic steroids for patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis

Limited published evidence indicates that AASs therapy provides clinical benefits in patients with COPD, however, longer and larger studies are needed to better clarify the efficacy of Aass and draw final conclusions.

Effects of Anabolic Steroids on Chronic Obstructive Pulmonary Disease: A Meta-Analysis of Randomised Controlled Trials

Limited evidence available from the published literature suggests that the benefit of anabolic steroids on COPD patients cannot be denied, but further studies are needed to identify the specific benefits and adverse effects of anabolism on COPd patients and to determine the optimal populations and regimes.

Emerging therapies for the treatment of skeletal muscle wasting in chronic obstructive pulmonary disease.

Testostéronémie et bronchopneumopathie chronique obstructive

Musculoskeletal Disorders in Chronic Obstructive Pulmonary Disease

This review will focus on skeletal muscle weakness and osteoporosis, their prevalence in COPD, combined risk factors, and pathogenesis, and try to prove the clustering of these comorbidities.

Do Androgens Modulate the Pathophysiological Pathways of Inflammation? Appraising the Contemporary Evidence

It is suggested that testosterone therapy attenuates the inflammatory process and reduces the burden of disease by mechanisms inhibiting inflammatory cytokine expression and function.

Beyond testosterone cypionate: evidence behind the use of nandrolone in male health and wellness

  • M. PanJ. Kovac
  • Biology, Medicine
    Translational andrology and urology
  • 2016
An anabolic steroid, 19-nortestosterone (i.e., nandrolone, deca-durabolin) has a higher myotrophic: androgenic ratio resulting in improved effects on muscle mass and animal models have suggested application in the improvement of joint healing following rotator cuff repair.

Impact of Body Mass Index Change on the Prognosis of Chronic Obstructive Pulmonary Disease

It is demonstrated that BMI decrease during follow-up was independently associated with exacerbation and higher mortality of COPD, suggesting BMI reduction in COPD should be carefully managed.

Body Mass Index and Mortality in Chronic Obstructive Pulmonary Disease: A Meta-Analysis

It was showed that for patients with COPD being overweight or obese had a protective effect against mortality, however, the relationship between BMI and mortality in different classes of obesity needed further clarification in well-designed clinical studies.

Sex Differences in Muscle Wasting.

The similarities and differences between men and women with common wasting conditions including sarcopenia and cachexia due to cancer, end-stage renal disease/chronic kidney disease, liver disease, chronic heart failure, and chronic obstructive pulmonary disease are reviewed.

References

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