Should androgenic anabolic steroids be considered in the treatment regime of selected chronic obstructive pulmonary disease patients?

  title={Should androgenic anabolic steroids be considered in the treatment regime of selected chronic obstructive pulmonary disease patients?},
  author={Marieke S Velema and Bibi H B Kwa and W de Ronde},
  journal={Current Opinion in Pulmonary Medicine},
Purpose of review Chronic obstructive pulmonary disease (COPD) is a widespread disease with high morbidity rates. Advanced stages can be complicated by unintentional weight loss and muscle wasting, which may contribute to increased morbidity and mortality. Reversal of weight loss increases muscle strength and exercise capacity and improves survival. This can partly be achieved by nutritional support, preferably combined with increase in exercise. Androgenic anabolic steroids (AASs), of which… 

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  • Biology, Medicine
    Translational andrology and urology
  • 2016
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Nutritional supplementation in combination with a short course of anabolic steroids may enhance the gain in FFM and respiratory muscle function in depleted patients with COPD without causing adverse side effects.

Reversal of COPD-associated weight loss using the anabolic agent oxandrolone.

Oxandrolone was relatively well tolerated and, therefore, should be a consideration in the comprehensive management of patients with COPD and weight loss.

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It is concluded that oral dietary supplements have no important effects on RM performance in ambulatory patients with COPD.