Should Growth Hormone Doses Be Increased during Puberty?


Physiological growth hormone (GH) secretion increases during puberty and it has been suggested that similar changes should be made to the therapeutic schedules of GH-insufficient children receiving GH therapy. We have tested this hypothesis in 50 GH-insufficient children aged between 9.7 and 14.5 years who were randomised to continue with biosynthetic human… (More)
DOI: 10.1203/00006450-199305001-00202