Shotgun sequence assembly and recent segmental duplications within the human genome

@article{She2004ShotgunSA,
  title={Shotgun sequence assembly and recent segmental duplications within the human genome},
  author={Xinwei She and Zhaoshi Jiang and Royden A. Clark and Ge Liu and Ze Cheng and Eray Tuzun and Deanna M. Church and Granger Sutton and Aaron L. Halpern and Evan E. Eichler},
  journal={Nature},
  year={2004},
  volume={431},
  pages={927-930}
}
Complex eukaryotic genomes are now being sequenced at an accelerated pace primarily using whole-genome shotgun (WGS) sequence assembly approaches. WGS assembly was initially criticized because of its perceived inability to resolve repeat structures within genomes. Here, we quantify the effect of WGS sequence assembly on large, highly similar repeats by comparison of the segmental duplication content of two different human genome assemblies. Our analysis shows that large (> 15 kilobases) and… CONTINUE READING
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