Shotgun proteomics implicates extracellular matrix proteins and protease systems in neuronal development induced by astrocyte cholinergic stimulation.

@article{Moore2009ShotgunPI,
  title={Shotgun proteomics implicates extracellular matrix proteins and protease systems in neuronal development induced by astrocyte cholinergic stimulation.},
  author={Nadia H. Moore and Lucio Guido Costa and Scott A Shaffer and David R. Goodlett and Marina Guizzetti},
  journal={Journal of neurochemistry},
  year={2009},
  volume={108 4},
  pages={891-908}
}
Astrocytes play an important role in neuronal development through the release of soluble factors that affect neuronal maturation. Shotgun proteomics followed by gene ontology analysis was used in this study to identify proteins present in the conditioned medium of primary rat astrocytes. One hundred and thirty three secreted proteins were identified, the… CONTINUE READING