Shotgun proteomics analysis of hibernating arctic ground squirrels.

@article{Shao2010ShotgunPA,
  title={Shotgun proteomics analysis of hibernating arctic ground squirrels.},
  author={Chunxuan Shao and Yuting Liu and Hongqiang Ruan and Ying Li and Haifang Wang and Franziska Kohl and Anna V. Goropashnaya and Vadim B. Fedorov and Rong Zeng and Brian M. Barnes and Jun Yan},
  journal={Molecular & cellular proteomics : MCP},
  year={2010},
  volume={9 2},
  pages={
          313-26
        }
}
Mammalian hibernation involves complex mechanisms of metabolic reprogramming and tissue protection. Previous gene expression studies of hibernation have mainly focused on changes at the mRNA level. Large scale proteomics studies on hibernation have lagged behind largely because of the lack of an adequate protein database specific for hibernating species. We constructed a ground squirrel protein database for protein identification and used a label-free shotgun proteomics approach to analyze… CONTINUE READING

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