Shortest-Path Network Analysis Is a Useful Approach toward Identifying Genetic Determinants of Longevity

@article{Managbanag2008ShortestPathNA,
  title={Shortest-Path Network Analysis Is a Useful Approach toward Identifying Genetic Determinants of Longevity},
  author={Jim Ray Managbanag and Tarynn M. Witten and Danail G. Bonchev and Lindsay A. Fox and Mitsuhiro Tsuchiya and Brian Kennedy and Matt Kaeberlein},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={101 - 113}
}
BACKGROUND Identification of genes that modulate longevity is a major focus of aging-related research and an area of intense public interest. In addition to facilitating an improved understanding of the basic mechanisms of aging, such genes represent potential targets for therapeutic intervention in multiple age-associated diseases, including cancer, heart disease, diabetes, and neurodegenerative disorders. To date, however, targeted efforts at identifying longevity-associated genes have been… CONTINUE READING

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Yeast lifespan extension by depletion of 60S ribosomal subunits is mediated by Gcn4. Cell

  • KK Steffan, VL MacKay, EO Kerr, M Tsuchiya, D Hu
  • 2008
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Yeast lifespan extension by depletion of 60 S ribosomal subunits is mediated by Gcn 4

  • KK Steffan, VL MacKay, EO Kerr, M Tsuchiya, D Hu
  • 2008

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