Shorter telomere length is associated with increased ovarian cancer risk in both familial and sporadic cases.

@article{MartnezDelgado2012ShorterTL,
  title={Shorter telomere length is associated with increased ovarian cancer risk in both familial and sporadic cases.},
  author={Beatriz Mart{\'i}nez-Delgado and Kira Yanowsky and Luc{\'i}a Inglada-P{\'e}rez and Miguel de la Hoya and Trinidad Caldes and Ana Mar{\'i}n Vega and Ana Blanco and Teresa Vel{\'a}zquez Mart{\'i}n and Rogelio Gonz{\'a}lez-Sarmiento and Mar{\'i}a Blasco and Mercedes Robledo and Miguel Urioste and Honglin Song and Paul D P Pharoah and Javier Ben{\'i}tez},
  journal={Journal of medical genetics},
  year={2012},
  volume={49 5},
  pages={341-4}
}
BACKGROUND Alterations in telomere maintenance mechanisms leading to short telomeres underlie different genetic disorders of ageing and cancer predisposition syndromes. It is known that short telomeres and subsequent genomic instability contribute to malignant transformation, and it is therefore likely that people with shorter telomeres are at higher risk for different types of cancer. Recently, the authors demonstrated that the genes BRCA1 and BRCA2 are modifiers of telomere length (TL) in… CONTINUE READING
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