Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage.

@article{Giorgi1999ShorterSI,
  title={Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage.},
  author={Janis V. Giorgi and Lance E. Hultin and Jane A McKeating and Timothy D. Johnson and Betty R. Owens and Lisa Paula Jacobson and Roger Y W Shih and Je Rey B. Lewis and Dorothy J Wiley and John P. Phair and Steven M. Wolinsky and Roger Detels},
  journal={The Journal of infectious diseases},
  year={1999},
  volume={179 4},
  pages={
          859-70
        }
}
To define predictors of survival time in late human immunodeficiency virus type 1 (HIV-1) disease, long- and short-duration survivors were studied after their CD4+ T cells fell to </=50/mm3. Immune activation of CD4+ and CD8+ T cells, as measured by elevated cell surface expression of CD38 antigen, was strongly associated with shorter subsequent survival (P</=.002). The naive CD45RA+CD62L+ T cell reserve was low in all subjects and did not predict survival (P=.34 for CD4+ and.08 for CD8+ cells… CONTINUE READING

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