Shortening of telomeres: Evidence for replicative senescence of T cells derived from patients with Wegener's granulomatosis.

@article{Vogt2003ShorteningOT,
  title={Shortening of telomeres: Evidence for replicative senescence of T cells derived from patients with Wegener's granulomatosis.},
  author={Saskia Vogt and Christof Iking-Konert and F. Hug and Konrad Andrassy and Gertrud Maria Haensch},
  journal={Kidney international},
  year={2003},
  volume={63 6},
  pages={2144-51}
}
BACKGROUND Replicative senescence describes the fact that somatic cells undergo a finite and predictable number of cell divisions before entering an irreversible state of growth arrest. Progressive shortening of the telomeres, a consequence of cell division, is a reliable indicator of replicative senescence. METHOD We analyzed telomere length of DNA derived from T cells of patients suffering from Wegener's granulomatosis by Southern blotting. Moreover, expression of CD28, another marker for… CONTINUE READING

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