Shortening of life span caused by administration of 5-bromodeoxyuridine to neonatal rats.

  title={Shortening of life span caused by administration of 5-bromodeoxyuridine to neonatal rats.},
  author={V. Craddock},
  journal={Chemico-biological interactions},
  volume={35 2},
  • V. Craddock
  • Published 1981
  • Biology, Medicine
  • Chemico-biological interactions
  • Newborn rats and adult animals in which liver cell replication had been induced by partial hepatectomy were injected with 5-bromodeoxyuridine (BUdR), and were kept without further treatment for the remainder of their life span. No evidence for carcinogenicity of BUdR was obtained, but a dose-dependent shortening of the life span was observed after administration to neonatal animals. 
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