Shortening of life span caused by administration of 5-bromodeoxyuridine to neonatal rats.

@article{Craddock1981ShorteningOL,
  title={Shortening of life span caused by administration of 5-bromodeoxyuridine to neonatal rats.},
  author={V. Craddock},
  journal={Chemico-biological interactions},
  year={1981},
  volume={35 2},
  pages={
          139-44
        }
}
  • V. Craddock
  • Published 1981
  • Biology, Medicine
  • Chemico-biological interactions
    • Newborn rats and adult animals in which liver cell replication had been induced by partial hepatectomy were injected with 5-bromodeoxyuridine (BUdR), and were kept without further treatment for the remainder of their life span. No evidence for carcinogenicity of BUdR was obtained, but a dose-dependent shortening of the life span was observed after administration to neonatal animals. 
    View on PubMed
    doi.org
    15 Citations
    Highly Influential Citations
    1
    Background Citations
    2
    Methods Citations
    1

    Topics from this paper

    Explore Further: Topics Discussed in This Paper

      15 Citations
      Citation Type

      Citation Type

      Effect of neonatal exposure to 5-bromo-2'-deoxyuridine on life span, estrus function and tumor development in rats--an argument in favor of the mutation theory of aging?
      • 19
      Life span reduction and carcinogenesis in the progeny of rats exposed neonatally to 5-bromo-2'-deoxyuridine.
      • 4
      5-Bromodeoxyuridine-induced carcinogenesis and its modification by persistent estrus syndrome, unilateral nephrectomy, and X-irradiation in rats.
      • 36
      • PDF
      Incorporation and persistence of 5-bromodeoxy-uridine in newborn rat tissue DNA
      • 13
      Carcinogenesis induced by neonatal exposure to various doses of 5-bromo-2'-deoxyuridine in rats.
      • 8
      Effects of 5-Azacytidine(5-AzC), 5-Bromodeoxyuridine(BrdU) and Diethyldithiocarbamate (DEDTC) on Diethylnitrosamine (DEN)-Induced Carcinogenesis in Rats
      • 1
      Multiorgan transplacental and neonatal carcinogenicity of 3'-azido-3'-deoxythymidine in mice.
      • 71
      The Chronic Toxicity of Bromovinyldeoxyuridine in Beagle Dogs
      • 1
      The Sole DNA Damage Induced by Bromodeoxyuridine Is Sufficient for Initiation of Both Aging and Carcinogenesis in Vivo
      • V. Anisimov
      • Biology, Medicine
      • Annals of the New York Academy of Sciences
      • 1994
      • 17
      Importance of the route of administration for genetic differences in benzo[a]pyrene-induced in utero toxicity and teratogenicity.
      • 78

      References

      SHOWING 1-10 OF 25 REFERENCES
      Polydactylism in the Offspring of Mice Injected with 5-Bromodeoxyuridine
      • 49
      The teratogenic response of mouse embryos to 5-bromodeoxyuridine.
      • 70
      Incorporation of 5-bromodeoxyuridine into DNA in newborn rat tissues.
      • 7
      Preferential inhibition by 5-bromodeoxyuridine of the synthesis of tyrosine aminotransferase in hepatoma cell cultures.
      • 120
      Thymomas induced by simple alkylating agents in C57BL/Cbi mice: kinetics of the dose response.
      • 36
      The role of thymidylate synthetase inhibitors in bromodeoxyuridine-induced neoplasia in Drosophila.
      • 9
      • PDF
      Effect of a single treatment with the alkylating carcinogens dimethylnitrosamine, diethylnitrosamine and methyl methanesulphonate, on liver regenerating after partial hepatectomy. II. Alkylation of DNA and inhibition of DNA replication.
      • 54
      Increased sensitivity of mammalian cell cultures to radiomimetic alkylating agents following incorporation of 5-bromodeoxyuridine into cellular DNA.
      • 18
      On the mechanism of 5-bromodeoxyuridine inhibition of exocrine pancreas differentiation.
      • 63
      Rat C-type virus induced in rat sarcoma cells by 5-bromodeoxyuridine.
      • 40