Shortening of life span caused by administration of 5-bromodeoxyuridine to neonatal rats.

@article{Craddock1981ShorteningOL,
  title={Shortening of life span caused by administration of 5-bromodeoxyuridine to neonatal rats.},
  author={V. Craddock},
  journal={Chemico-biological interactions},
  year={1981},
  volume={35 2},
  pages={
          139-44
        }
}
  • V. Craddock
  • Published 1981
  • Biology, Medicine
  • Chemico-biological interactions
  • Newborn rats and adult animals in which liver cell replication had been induced by partial hepatectomy were injected with 5-bromodeoxyuridine (BUdR), and were kept without further treatment for the remainder of their life span. No evidence for carcinogenicity of BUdR was obtained, but a dose-dependent shortening of the life span was observed after administration to neonatal animals. 
    15 Citations

    Topics from this paper

    Multiorgan transplacental and neonatal carcinogenicity of 3'-azido-3'-deoxythymidine in mice.
    • 71
    The Sole DNA Damage Induced by Bromodeoxyuridine Is Sufficient for Initiation of Both Aging and Carcinogenesis in Vivo
    • V. Anisimov
    • Biology, Medicine
    • Annals of the New York Academy of Sciences
    • 1994
    • 17

    References

    SHOWING 1-10 OF 25 REFERENCES
    Incorporation of 5-bromodeoxyuridine into DNA in newborn rat tissues.
    • 7
    Thymomas induced by simple alkylating agents in C57BL/Cbi mice: kinetics of the dose response.
    • 36
    On the mechanism of 5-bromodeoxyuridine inhibition of exocrine pancreas differentiation.
    • 63
    Rat C-type virus induced in rat sarcoma cells by 5-bromodeoxyuridine.
    • 40