Shortening of cardiac action potential duration near an insulating boundary.

  title={Shortening of cardiac action potential duration near an insulating boundary.},
  author={John W. Cain and David G. Schaeffer},
  journal={Mathematical medicine and biology : a journal of the IMA},
  volume={25 1},
It is known, from both experiments and simulations, that cardiac action potentials are shortened near a non-conducting boundary. In the present paper, this effect is studied in a simple, two-current ionic model, with propagation restricted to a 1D fibre. An asymptotic approximation for the dependence of action potential duration on distance to the boundary is derived. This estimate agrees well with simulations. 


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Feedback Control of Cardiac Alternans, (Invited) Society of Industrial and Applied Mathematics

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Speed versus Robustness in Feed-Forward Biochemical Reaction Networks, (Invited

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Modeling the Dynamics of FeedForward Biological Networks, Special Session on Research by Undergraduates

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