Shortening and Improving the Embryonic Stem Cell Test through the Use of Gene Biomarkers of Differentiation


The embryonic Stem cell Test (EST) is a validated assay for testing embryotoxicity in vitro. The total duration of this protocol is 10 days, and its main end-point is based on histological determinations. It is suggested that improvements on EST must be focused toward molecular end-points and, if possible, to reduce the total assay duration. Five days of… (More)
DOI: 10.1155/2011/286034

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