Shortcomings in the current treatment of epilepsy

@article{Eadie2012ShortcomingsIT,
  title={Shortcomings in the current treatment of epilepsy},
  author={M. Eadie},
  journal={Expert Review of Neurotherapeutics},
  year={2012},
  volume={12},
  pages={1419 - 1427}
}
  • M. Eadie
  • Published 2012
  • Medicine
  • Expert Review of Neurotherapeutics
Contemporary drug therapy fails to control epileptic seizures in some 30% of patients, resulting in the need to employ other measures when they appear practicable. A good deal of potentially relevant statistical detail is available regarding the outcomes of the available antiepileptic therapies, but its interpretation is sometimes difficult because of uncertainty about the types of epilepsy to which it applies, and because of deficiencies in knowledge of the natural histories of the various… Expand
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References

SHOWING 1-10 OF 85 REFERENCES
Some Aspects of Prognosis in the Epilepsies: A Review
TLDR
Factors that may influence the prognosis of the epilepsies, including the problems of diagnosis, are reviewed and special emphasis is given to the issue of spontaneous remission and the question of prog outlook of different epileptic syndromes. Expand
Do anticonvulsants alter the natural course of epilepsy? Treatment should be started as early as possible.
TLDR
It is suggested that antiepileptic drugs may also influence the natural history of epilepsy, that epilepsy should be viewed as a process that has the potential to develop into an intractable disorder, and that early effective treatment may reduce this risk of chronicity. Expand
Refractory Epilepsy: Clinical Overview
TLDR
Pharmacogeneticists are currently attempting to understand the genetic basis of refractory epilepsy so that they can identify subgroups of patients who share a common genetic background and then target drug therapies to meet their specific needs. Expand
Diagnosing and predicting refractory epilepsy
  • M. Brodie
  • Medicine
  • Acta neurologica Scandinavica. Supplementum
  • 2005
TLDR
Patients with symptomatic or cryptogenic epilepsy, those who experience multiple seizures before AED treatment initiation, and those with febrile convulsions, a family history of epilepsy, or psychiatric comorbidities are least likely to respond to drug therapy. Expand
Early identification of refractory epilepsy.
TLDR
Patients who have many seizures before therapy or who have an inadequate response to initial treatment with antiepileptic drugs are likely to have refractory epilepsy. Expand
Prognosis of chronic and newly diagnosed epilepsy: revisiting temporal aspects
TLDR
The importance of taking a synoptical view of prognosis, incorporating temporal aspects, in making clinical prognostic predictions in epilepsy is confirmed. Expand
Current limitations of antiepileptic drug therapy: a conference review
The current limitations of antiepileptic drug (AED) therapy were the topic of a discussion group meeting at the 5th European Congress on Epileptology, Madrid, 6-10 October 2002. This review containsExpand
Does Antiepileptic Drug Therapy Prevent the Development of “Chronic” Epilepsy?
TLDR
The available data suggest that the natural history of seizure disorders is often self-limited and that early intervention with AED therapy does not alter the long-term prognosis of seizures and epilepsy. Expand
Diagnosing refractory epilepsy: response to sequential treatment schedules
TLDR
The data suggest that suitable patients failing two AED regimens should be referred for epilepsy surgery, and those who do not attain long‐term seizure freedom with the first three treatment schedules are likely to have refractory epilepsy. Expand
Treatment of first tonic-clonic seizure does not improve the prognosis of epilepsy
TLDR
Patients treated after the first seizure and those treated after seizure relapse had the same time-dependent probability of achieving 1 and 2 seizure-free years, and none of the variables that were prognostic predictors of relapse was significantly associated with the probability of having 1 or 2 years of seizure control. Expand
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