Shortcomings in the current treatment of epilepsy

  title={Shortcomings in the current treatment of epilepsy},
  author={Mervyn John Eadie},
  journal={Expert Review of Neurotherapeutics},
  pages={1419 - 1427}
  • M. Eadie
  • Published 1 December 2012
  • Psychology, Medicine
  • Expert Review of Neurotherapeutics
Contemporary drug therapy fails to control epileptic seizures in some 30% of patients, resulting in the need to employ other measures when they appear practicable. A good deal of potentially relevant statistical detail is available regarding the outcomes of the available antiepileptic therapies, but its interpretation is sometimes difficult because of uncertainty about the types of epilepsy to which it applies, and because of deficiencies in knowledge of the natural histories of the various… 

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  • 1961
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Pharmacogeneticists are currently attempting to understand the genetic basis of refractory epilepsy so that they can identify subgroups of patients who share a common genetic background and then target drug therapies to meet their specific needs.

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Patients with symptomatic or cryptogenic epilepsy, those who experience multiple seizures before AED treatment initiation, and those with febrile convulsions, a family history of epilepsy, or psychiatric comorbidities are least likely to respond to drug therapy.

Early identification of refractory epilepsy.

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Prognosis of chronic and newly diagnosed epilepsy: revisiting temporal aspects

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The data suggest that suitable patients failing two AED regimens should be referred for epilepsy surgery, and those who do not attain long‐term seizure freedom with the first three treatment schedules are likely to have refractory epilepsy.