Short-time cytotoxicity of mussel extracts: a new bioassay for okadaic acid detection.

@article{Amzil1992ShorttimeCO,
  title={Short-time cytotoxicity of mussel extracts: a new bioassay for okadaic acid detection.},
  author={Zouher Amzil and Yves François Pouchus and J Le Boterff and Christos Roussakis and Jean François Verbist and C Marcaillou-Lebaut and Pascal Masselin},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={1992},
  volume={30 11},
  pages={1419-25}
}
Okadaic acid (OA), the main toxin responsible for diarrhoeic shellfish poisoning (DSP) has high cytotoxicity for KB cell cultures (apparent after 3 hr of contact), facilitating rapid detection in contaminated mussels. We developed a method to determine the minimal active concentration (MAC) based on direct microscopic study of toxin-induced changes in cell morphology. A high correlation was found between the MAC of tested extracts and corresponding OA concentrations in mussel hepatopancreas as… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

Similar Papers

Loading similar papers…