Short-term treatment with high-dose atorvastatin reduces LDL cholesterol but shows no anti-inflammatory effects in normolipidemic subjects with normal CRP levels.

@article{Millar2010ShorttermTW,
  title={Short-term treatment with high-dose atorvastatin reduces LDL cholesterol but shows no anti-inflammatory effects in normolipidemic subjects with normal CRP levels.},
  author={John S Millar and Bonnie Ky and Megan L. Wolfe and Leticia Pruscino and Amanda L. Baer and Daniel J. Rader},
  journal={Clinical and translational science},
  year={2010},
  volume={3 4},
  pages={
          140-6
        }
}

• John S Millar, Bonnie Ky, +3 authors Daniel J. Rader
• Published 2010 in Clinical and translational science
• DOI:10.1111/j.1752-8062.2010.00211.x

The benefit in reducing cardiovascular risk with statins has been attributed both to cholesterol lowering and pleiotropic effects. These pleiotropic effects are thought to include attenuation of the inflammatory response due to reduced prenylation of proteins in the inflammatory cascade. We conducted studies in normolipidemic subjects to determine if treatment with high-dose (80 mg) atorvastatin could reduce circulating levels of inflammatory markers. We also determined whether high-dose… CONTINUE READING

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