Short-term treatment with a beta-blocker with vasodilative capacities improves intrarenal endothelial function in experimental renal failure.

@article{Gschwend2009ShorttermTW,
  title={Short-term treatment with a beta-blocker with vasodilative capacities improves intrarenal endothelial function in experimental renal failure.},
  author={Simone Gschwend and Marcel Bernhard Haug and Marc Nierhaus and Angela Schulz and Roland Vetter and Peter Kossmehl and H Orzechowski and Juergen Scholze and Lars Rothermund and Reinhold Kreutz},
  journal={Life sciences},
  year={2009},
  volume={85 11-12},
  pages={
          431-7
        }
}
AIMS In patients with renal disease the cardiovascular risk is greatly increased, and endothelial dysfunction is assumed to play a pivotal role in this process. Therefore we compared treatment effects of a beta-blocker with additional vasodilatory capacities (nebivolol) and a beta-blocker lacking these actions (metoprolol) on intrarenal and coronary vascular function in a rat model of renal failure with hypertension. MAIN METHODS Renal failure was induced by 5/6-nephrectomy (Nx) and analyzed… CONTINUE READING
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