Short-term therapy of severe hypertension. Hemodynamic correlates of the antihypertensive response in man.

@article{Sullivan1979ShorttermTO,
  title={Short-term therapy of severe hypertension. Hemodynamic correlates of the antihypertensive response in man.},
  author={Jay M. Sullivan and A A Schoeneberger and T E Ratts and E T Palmer and Joseph Samaha and C J Mance and E. Eric Muirhead},
  journal={Archives of internal medicine},
  year={1979},
  volume={139 11},
  pages={1233-9}
}
Ten severely hypertensive patients were randomized into five treatment groups: vasodilators; vasodilators plus diuretics; sympatholytics; sympatholytics plus diuretics; and sympatholytics, diuretics, and vasodialtors. Cardiac index was measured daily by echocardiography, and total peripheral resistance (TPR) calculated. Plasma renin activity (PRA) and creatinine clearance (CCR) were measured every other day. There was no difference in antihypertensive response. Seven patients, whose initial TPR… CONTINUE READING