Short-term therapy for streptococcal infective endocarditis. Combined intramuscular administration of penicillin and streptomycin.

@article{Wilson1981ShorttermTF,
  title={Short-term therapy for streptococcal infective endocarditis. Combined intramuscular administration of penicillin and streptomycin.},
  author={Walter R. Wilson and Rodney L. Thompson and C J Wilkowske and John A. Washington and E R Giuliani and Joseph E. Geraci},
  journal={JAMA},
  year={1981},
  volume={245 4},
  pages={360-3}
}
In a prospective study, 91 patients with penicillin-sensitive infective endocarditis (IE) were treated for two weeks with intramuscular (IM) penicillin G procaine, 1.2 million units every six hours, plus streptomycin sulfate, 500 mg IM every 12 hours. Viridans streptococci were isolated from 70 patients (77%); 21 patients (23%) had Streptococcus bovis infections. Eighteen patients (20%) had had symptoms of IE for three months or longer. Follow-up ranged from two months to 6.6 years. There were… CONTINUE READING