Short-term sleep deprivation with nocturnal light exposure alters time-dependent glucagon-like peptide-1 and insulin secretion in male volunteers.
@article{GilLozano2016ShorttermSD, title={Short-term sleep deprivation with nocturnal light exposure alters time-dependent glucagon-like peptide-1 and insulin secretion in male volunteers.}, author={Manuel Gil-Lozano and Paola M. Hunter and Lucy Ann Behan and Bojana Gladanac and Robert F. Casper and Patricia Lee Brubaker}, journal={American journal of physiology. Endocrinology and metabolism}, year={2016}, volume={310 1}, pages={ E41-50 } }
The intestinal L cell is the principal source of glucagon-like peptide-1 (GLP-1), a major determinant of insulin release. Because GLP-1 secretion is regulated in a circadian manner in rodents, we investigated whether the activity of the human L cell is also time sensitive. Rhythmic fluctuations in the mRNA levels of canonical clock genes were found in the human NCI-H716 L cell model, which also showed a time-dependent pattern in their response to well-established secretagogues. A diurnal…
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