Short-term sleep deprivation with nocturnal light exposure alters time-dependent glucagon-like peptide-1 and insulin secretion in male volunteers.

@article{GilLozano2016ShorttermSD,
  title={Short-term sleep deprivation with nocturnal light exposure alters time-dependent glucagon-like peptide-1 and insulin secretion in male volunteers.},
  author={Manuel Gil-Lozano and Paola M. Hunter and Lucy Ann Behan and Bojana Gladanac and Robert F. Casper and Patricia Lee Brubaker},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2016},
  volume={310 1},
  pages={
          E41-50
        }
}
The intestinal L cell is the principal source of glucagon-like peptide-1 (GLP-1), a major determinant of insulin release. Because GLP-1 secretion is regulated in a circadian manner in rodents, we investigated whether the activity of the human L cell is also time sensitive. Rhythmic fluctuations in the mRNA levels of canonical clock genes were found in the human NCI-H716 L cell model, which also showed a time-dependent pattern in their response to well-established secretagogues. A diurnal… 

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