Short-term significance of DNA ploidy and cell proliferation in breast carcinoma: a multivariate analysis of prognostic markers in a series of 308 patients.

@article{Pinto1999ShorttermSO,
  title={Short-term significance of DNA ploidy and cell proliferation in breast carcinoma: a multivariate analysis of prognostic markers in a series of 308 patients.},
  author={Ant{\'o}nio Evaristo Pinto and Saudade P Andr{\'e} and Jorge Fernando Maxnuck Soares},
  journal={Journal of clinical pathology},
  year={1999},
  volume={52 8},
  pages={604-11}
}
AIM To determine the importance of tumour DNA ploidy and cell proliferation, as measured by the S phase fraction (SPF), in relation to other established clinicopathological indicators of prognosis in breast cancer. METHODS A prospective study of 308 patients. Tumours were staged following the TNM system criteria and were classified according to the histological type and grade. DNA flow cytometry was performed on fresh/frozen samples stained with propidium iodide. Hormone receptors were… CONTINUE READING