Short-term reproducibility of a commercial interferon gamma release assay.

  title={Short-term reproducibility of a commercial interferon gamma release assay.},
  author={Anne Katrin Detjen and Laurianne Loebenberg and Harleen M. S. Grewal and Kim Stanley and Andrea Gutschmidt and Colin Kruger and Naude du Plessis and Martin Kidd and Nulda Beyers and Gerhard Walzl and Anneke Catharina Hesseling},
  journal={Clinical and vaccine immunology : CVI},
  volume={16 8},
Interferon gamma release assays (IGRAs) have been shown to be sensitive and highly specific for the detection of immune memory against Mycobacterium tuberculosis. Little is known about the reproducibility and within-person variability of these assays. Various aspects of short-term reproducibility of a commercial IGRA, the QuantiFERON-TB Gold In-Tube (QFT-IT) assay, were assessed. The QFT-IT assay was performed twice within 3 days in 27 health care workers in Cape Town, South Africa. Two sets of… CONTINUE READING

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