Short-term plasticity shapes the response to simulated normal and parkinsonian input patterns in the globus pallidus.

@article{Hanson2002ShorttermPS,
  title={Short-term plasticity shapes the response to simulated normal and parkinsonian input patterns in the globus pallidus.},
  author={Jesse E Hanson and Dieter Jaeger},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 12},
  pages={5164-72}
}
Basal ganglia structures show strong activity modulation during movement and synchronous bursting in Parkinson's disease. Recent work has shown that short-term synaptic plasticity (STP) can play an important role in the effect of temporal activity patterns on postsynaptic targets. To determine the role of STP in the subthalamic nucleus (STN) to globus pallidus (GP) connection, which has been suggested to underlie rhythmical bursting in Parkinson's disease, we first measured STP using trains of… CONTINUE READING

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