Short-term outcomes of platelet-rich plasma injection for treatment of osteoarthritis of the knee

@article{Kanchanatawan2015ShorttermOO,
  title={Short-term outcomes of platelet-rich plasma injection for treatment of osteoarthritis of the knee},
  author={Wichan Kanchanatawan and Alisara Arirachakaran and Kornkit Chaijenkij and Niti Prasathaporn and Manusak Boonard and Peerapong Piyapittayanun and Jatupon Kongtharvonskul},
  journal={Knee Surgery, Sports Traumatology, Arthroscopy},
  year={2015},
  volume={24},
  pages={1665-1677}
}
AbstractPurposeTo compare the clinical outcomes of osteoarthritis indices (WOMAC and Lequesne scores) and adverse events in the treatment of osteoarthritis (OA) of the knee with platelet-rich plasma (PRP) versus hyaluronic acid (HA) or placebo. MethodsA systematic review and meta-regression were performed to compare outcomes between PRP injections versus HA or placebo. Relevant randomized control trials were identified from Medline and Scopus from date of inception to 13 August 2015.ResultsNine… 
The effects of platelet-rich plasma injection in knee and hip osteoarthritis: a meta-analysis of randomized controlled trials
TLDR
Intra-articular PRP injection provided better effects than other injections for OA patients, especially in knee OA Patients, in terms of pain reduction and function improvement at short-term follow-up.
Role of Triple Injection Platelet-Rich Plasma for Osteoarthritis Knees: A 2 Years Follow-Up Study.
TLDR
Triple injection of intra-articular PRP given one month apart significantly relieves the symptoms of knee OA till 2 years in KL grade I, II and III, although the baseline scores had significant difference (p = 0.001 for both VAS and WOMAC).
Platelet-rich plasma versus hyaluronic acid in knee osteoarthritis: A meta-analysis with the consistent ratio of injection
TLDR
Based on the current evidence, PRP appears to be better than HA at achieving pain relief and self-reported functional improvement in Osteoarthritis patients.
Platelet Rich Plasma Versus Hyaluronic Acid in the Treatment of Knee Osteoarthritis: a Meta-Analysis of 26 randomized controlled trials.
  • Jixiang Tan, Hong Chen, Lin-Wei Zhao, Wei Huang
  • Medicine
    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
  • 2020
Platelet-Rich Plasma for the Management of Hip and Knee Osteoarthritis
TLDR
Results showed that PRP is a safe treatment with potential to provide symptomatic benefit for OA at least in the short term (up to 12 months), and younger patients with less severe disease may be more responsive.
The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials
TLDR
Intra-articular PRP injections probably are more efficacious in the treatment of knee OA in terms of pain relief and self-reported function improvement at 3, 6 and 12 months follow-up, compared with other injections, including saline placebo, HA, ozone, and corticosteroids.
Comparison of platelet-rich plasma vs hyaluronic acid injections in patients with knee osteoarthritis
TLDR
This proposed systematic review will provide up-to-date evidence to assess the effect of PRP treatment for patients with KOA and will provide a high-quality analysis of the current evidence supporting PRP.
Relative Efficacy of Intra-articular Injections in the Treatment of Knee Osteoarthritis: A Systematic Review and Network Meta-analysis.
TLDR
PRP yielded improved outcomes when compared with PRGF, HA, CS, and placebo for the treatment of symptomatic knee OA at a minimum 6-month follow-up, and was found to possess the highest probability of efficacy.
Efficacy of Platelet-Rich Plasma in Pain and Self-Report Function in Knee Osteoarthritis: A Best-Evidence Synthesis
TLDR
In relieving pain and improving self-report function, PRP showed no superiority over hyaluronic acid in well-designed double-blind trials, and beneficial effects of PRP in most trials probably resulted from insufficient blinding methods.
Efficacy of Platelet-Rich Plasma on Pain and Function in the Treatment of Knee Osteoarthritis: A Prospective Cohort Study
TLDR
Recommendation of repeated multiple injections up to four times is efficient in providing long time relief in knee OA.
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TLDR
PRP injections reduced pain more effectively than did placebo injections in OA of the knee (level of evidence: limited due to a high risk of bias) and this significant effect on pain was also seen when PRP injections were compared with hyaluronic acid injections.
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Treatment of Knee Joint Osteoarthritis with Autologous Platelet-Rich Plasma in Comparison with Hyaluronic Acid
TLDR
The preliminary findings support the application of autologous PRP as an effective and safe method in the treatment of the initial stages of knee osteoarthritis.
Treatment With Platelet-Rich Plasma Is More Effective Than Placebo for Knee Osteoarthritis
TLDR
A single dose of WBC-filtered PRP in concentrations of 10 times the normal amount is as effective as 2 injections to alleviate symptoms in early knee OA, but the results, however, deteriorate after 6 months.
Efficacy and safety of plasma rich in growth factors intra-articular infiltrations in the treatment of knee osteoarthritis.
Knee Osteoarthritis Injection Choices: Platelet- Rich Plasma (PRP) Versus Hyaluronic Acid (A one-year randomized clinical trial)
TLDR
It is suggested that PRP injection is more efficacious than HA injection in reducing symptoms and improving quality of life and is a therapeutic option in select patients with knee OA who have not responded to conventional treatment.
Platelet-rich plasma vs hyaluronic acid to treat knee degenerative pathology: study design and preliminary results of a randomized controlled trial
TLDR
Results suggest that PRP injections offer a significant clinical improvement up to one year of follow-up, and for middle-aged patients with moderate signs of OA, PRP results were not better than those obtained with HA injections, and thus it should not be considered as first line treatment.
Effect of Leukocyte Concentration on the Efficacy of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis
TLDR
LP-PRP results in improved functional outcome scores compared with hyaluronic acid and placebo when used for treatment of knee osteoarthritis and was the highest ranked treatment for both measures of clinical efficacy.
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