Short-term oral administration of L-arginine reverses defective endothelium-dependent relaxation and cGMP generation in diabetes.

@article{Pieper1996ShorttermOA,
  title={Short-term oral administration of L-arginine reverses defective endothelium-dependent relaxation and cGMP generation in diabetes.},
  author={Galen M. Pieper and Wolfgang Siebeneich and L. A. Dondlinger},
  journal={European journal of pharmacology},
  year={1996},
  volume={317 2-3},
  pages={317-20}
}
In the present study, we evaluated whether acute dietary supplementation with L-arginine in vivo could reverse the defective endothelium-dependent relaxation in diabetic blood vessels assessed ex vivo. At 8 weeks of diabetes, streptozotocin-induced diabetic rats were given 1.25% L-arginine in drinking water 3 days prior to isolation of aortic rings for evaluation ex vivo. Plasma arginine concentration was reduced by diabetes but restored to normal in diabetic rats receiving dietary L-arginine… CONTINUE READING