Short-term night-shift working mimics the pituitary-adrenocortical dysfunction in chronic fatigue syndrome.

@article{Leese1996ShorttermNW,
  title={Short-term night-shift working mimics the pituitary-adrenocortical dysfunction in chronic fatigue syndrome.},
  author={Graham Peter Leese and P Chattington and W. Fraser and Jiten Vora and Ray Edwards and G L Williams},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1996},
  volume={81 5},
  pages={1867-70}
}
The purpose of this study was to determine whether a short period (5 days) of night-shift work affected the pituitary-adrenal responses to CRH. Ten nurses (8 female and 2 male; age 28.1 +/- 1.7 yr: mean +/- SEM) working at the Royal Liverpool University Hospital, and who regularly undertook periods of night and day shift work were enrolled. Measurements were made of basal ACTH and cortisol concentrations, and their responses to iv ovine CRH (1 microgram.kg-1). Basal ACTH concentrations were… CONTINUE READING
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