Short-term naloxone administration in schizophrenic and manic patients. A World Health Organization Collaborative Study.

@article{Pickar1982ShorttermNA,
  title={Short-term naloxone administration in schizophrenic and manic patients. A World Health Organization Collaborative Study.},
  author={David Pickar and Felix Vartanian and William E. Bunney and Hans Maier and Markus T Gastpar and Ravi Prakash and B. B. Sethi and R. R. Lideman and B. S. Belyaev and M V Tsutsulkovskaja and Gerd Jungkunz and Norbert Nedopil and Willem Verhoeven and H N Van Praag},
  journal={Archives of general psychiatry},
  year={1982},
  volume={39 3},
  pages={313-9}
}
A double-blind study of the behavioral effects of short-term naloxone hydrochloride administration was performed in 32 schizophrenic and 26 manic patients in a World Health Organization collaborative project. There was a significant naloxone-associated reduction in overall physician-rated symptoms in schizophrenic patients concurrently treated with neuroleptic medication (N = 19) but not in medication-free schizophrenics (N = 13). Physician rating of auditory hallucinations showed significant… CONTINUE READING

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