Short-term metabolic effects of recombinant human insulin-like growth factor I in healthy adults.

@article{Guler1987ShorttermME,
  title={Short-term metabolic effects of recombinant human insulin-like growth factor I in healthy adults.},
  author={H P Guler and Juergen Zapf and E. Rudolf Froesch},
  journal={The New England journal of medicine},
  year={1987},
  volume={317 3},
  pages={137-40}
}
Insulin-like growth factor I (IGF I) is structurally similar to insulin and shares many of its biologic properties. We compared the short-term metabolic effects of recombinant IGF I (100 micrograms [13.3 nmol] per kilogram of body weight) and insulin (0.15 IU [1 nmol] per kilogram) in eight healthy volunteers (four men and four women). The hypoglycemic responses to both hormones were nearly identical in the doses used. The lowest blood glucose levels were reached after 30 minutes: 1.98 +/- 0.44… CONTINUE READING