Short-term mechanical stretch fails to differentiate human adipose-derived stem cells into cardiovascular cell phenotypes

@inproceedings{GiroSilva2014ShorttermMS,
  title={Short-term mechanical stretch fails to differentiate human adipose-derived stem cells into cardiovascular cell phenotypes},
  author={Thais Gir{\~a}o-Silva and Vin{\'i}cius Bassaneze and Luciene Cristina Gastalho Campos and Val{\'e}rio G Barauna and Lu{\'i}s Alberto de Oliveira Dallan and Jos{\'e} Eduardo Krieger and Ayumi A Miyakawa},
  booktitle={Biomedical engineering online},
  year={2014}
}
BACKGROUND We and others have previously demonstrated that adipose-derived stem cells (ASCs) transplantation improve cardiac dysfunction post-myocardium infarction (MI) under hemodynamic stress in rats. The beneficial effects appear to be associated with pleiotropic factors due to a complex interplay between the transplanted ASCs and the microenvironment in the absence of cell transdifferentiation. In the present work, we tested the hypothesis that mechanical stretch per se could change human… CONTINUE READING