Short-term intratumoral interleukin-12 expressed from an alphaviral vector is sufficient to induce an efficient antitumoral response against spontaneous hepatocellular carcinomas.

@article{RodriguezMadoz2014ShorttermII,
  title={Short-term intratumoral interleukin-12 expressed from an alphaviral vector is sufficient to induce an efficient antitumoral response against spontaneous hepatocellular carcinomas.},
  author={Juan Roberto Rodriguez-Madoz and Maider Zabala and Maite Alfaro and Jes{\'u}s Prieto and Maria Gabriela Kramer and Cristian Smerdou},
  journal={Human gene therapy},
  year={2014},
  volume={25 2},
  pages={132-43}
}
Interleukin-12 (IL-12) is an immunostimulatory cytokine that has shown strong antitumor effects in animal models of liver cancer. In order to overcome the severe toxicity associated with its systemic administration, we had previously tested different strategies based on IL-12 gene transfer to tumor cells or to the surrounding liver tissue. We obtained promising results both with a recombinant Semliki Forest virus (SFV) vector expressing high levels of IL-12 (SFV-IL-12) after intratumoral… CONTINUE READING
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