Short-term intensive atorvastatin therapy improves endothelial function partly via attenuating perivascular adipose tissue inflammation through 5-lipoxygenase pathway in hyperlipidemic rabbits.

@article{Wang2014ShorttermIA,
  title={Short-term intensive atorvastatin therapy improves endothelial function partly via attenuating perivascular adipose tissue inflammation through 5-lipoxygenase pathway in hyperlipidemic rabbits.},
  author={Xiaoqiao Wang and Yongqin Lin and Niansang Luo and Zhongqing Chen and Miaoning Gu and Jingfeng Wang and Yangxin Chen},
  journal={Chinese medical journal},
  year={2014},
  volume={127 16},
  pages={2953-9}
}
BACKGROUND Atherosclerosis is a kind of disease with multiple risk factors, of which hyperlipidemia is a major classical risk factor resulting in its pathogenesis and development. The aim of this study was to determine the effects of short-term intensive atorvastatin (IA) therapy on vascular endothelial function and explore the possible mechanisms that may help to explain the clinical benefits from short-term intensive statin therapy. METHODS After exposure to high-fat diet (HFD) for 8 weeks… CONTINUE READING
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